Single Molecule Analysis in Real-Time (SMART) Center

Welcome to the University of Michigan's Single Molecule Analysis in Real-Time (SMART) Center

ImageIn recent years a revolution has occurred in the basic sciences, which exploits novel single molecule detection and manipulation tools to track and analyze biomolecules in unprecedented detail. The goal of the SMART Center is to develop a university-wide initiative in the emerging area of single molecule technology, including single molecule spectroscopy (SMS) and imaging (SMI), laser tweezers (LT), and atomic force microscopy (AFM), to bring basic scientists, engineers, and clinical researchers together to apply this technology to the most relevant questions in medicine and nanotechnology. This initiative will thus build on the momentum established by the State's creation of the Michigan LifeScience Corridor (MLSC) Core Technology Alliance for single molecule spectroscopy at Michigan.

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2nd Midwest Single Molecule Workshop

Welcome to the website of the second Midwest Single Molecule Workshop, to be held on Thursday/Friday, July 26-27, 2012, on the campus of the University of Michigan in Ann Arbor. This workshop gathers the leading single molecule microscopy researchers from all across the Midwest (loosely defined!) to share their ideas, research and resources.

For registration and housing information, please go to Thanks to a number of sponsors, we will be able to keep the registration fee at $100 per person, even with the expanded program. If you need help with logistics, please contact Ms. Ann Titus ( This e-mail address is being protected from spam bots, you need JavaScript enabled to view it ), for questions related to the scientific program, Nils and I will be happy to help you.

Jens-Christian Meiners and Nils Walter

- (10/01/2011) -  Following successful conclusion of the SMART Center's NSF-funded seed grant, the Center has successfully transitioned to a sustaining funding model.  Read the Project Outcomes Report for the General Public here. 
- (05/27/2011) - US News coverage of the Center: "Studying Single Molecules ".
- (03/28/2011) - The SMART Lab facility will officially open on April 4th 2011 at 3080 Chemistry. See the highlight in the University of Michigan Record Online (March 28th 2011) .
- (09/01/2010) - A new research scientist has been hired: Tristan Tabouillot will be in charge of setting up the equipment and managing the facility.